The other day I was going 70 mph (at) 3500rpm and I could look down every five minutes and see the gas gauge go lower and lower.
I have watched my gas gauge go down almost a quarter tank on my drive home when I go over 70mph.

... speed definitely makes a difference. couldn't imagine going any real distance with all under 2000 rpm. my jeep doesn't come to life until 2000k (aka if you want to have a chance to maintain speed on a hill in 4th) and gets nice around 2500rpm.