I'm running 4.88's, and I agree with Jeffy... It's not the R&P to worry about, it's the axle.
My rear is a 9", so with a 4cyl, I should never have to worry (fingers crossed). The front is a D30 that's 30 spline, so the weak link there is the smaller pinion gear. I'm running the small bolt pattern hubs, so I hope that the hub breaks (I carry spares) before the pinion breaks.
Another aspect to consider is... Stock, almost all 4 cyl. engines came with 4.10's... the next step up is 4.56. But in percentages, that's a .899, or 10% difference. (Side note that 4.88's are a .84 or 16% difference).
Now do that with tires... a 33" tire from a 28" (althought stock may be closer to 27"), but that is a .848, or a 15% difference.
With that said, to chose the best ratio ask, how close to stock (or better) do you wanna get?