I've been running acetone in my gas on and off since last summer. I have to say that with acetone in the tank, I get about 225 miles per tank, whereas I used to get 200 pretty consistently. I usually put in one or two ounces per fillup, with a 15 gallon tank. I have 31" tires, stock gearing, 62mm TB, hi flow exhaust, 1.5 inch shackle lift, so, nothing hugely different from stock. The only change I've made that seemed to positively affect the MPG was the acetone. My last tank was 204 miles and 12.4 gallons, and the tank before that was 225 miles and 13.3 gallons, driving 42 miles to work every day at 75 to 80 miles per hour. Once over a long weekend I was able to push 254 out of a tank, that made me really happy. So, go with the acetone, it isn't any worse of a solvent than gasoline is at those quantities, and let us know what kind of results you get.