The question is a mouthfull of opinions. There are a lot of variables to take to consider an answer. Wheel/tire size, typical terrain for offroading, how much time and effort, how much money, your goals of the use, etc.
However, if you are looking at swapping in the front axle off the 79 F250, this would be a great upgrade to the stock YJ front axle. It would be a D44 with 3" tubes with 1/2" wall. To add, the leaf mount difference between the YJ and the F250 is little more than 1/2". So basically, the front axle will bolt right underneath the stock YJ leafs. Then you have to configure shocks, steering, brakes, wheels, matching gear ratios to the axles, etc. You could also use the rear axle as well, but that would require little more work with welding spring perches and shock mounts on. Nothing major but still welding to get the axles underneath.
To add, you may luck out as well and the F250 may be a Snowfighter option which gives you a D60 front axle. Either way, both are big and heavy front axles compared to your stock YJ axle.